As Mark Twain noted, "It ain't what you don't know that gets you into trouble. It's what you know for sure that just ain't so." The critical issue is one of measurement of progesterone. The assays are simply not accurate (consistent, replicable) in the levels that are being measured. I suspect that there is likely an effect of premature luteinization on endometrial receptivity, but where the progesterone threshold lies is far from settled. There are lots of major programs that do not measure serum progesterone levels. Perhaps the missing piece is a study comparing the various progesterone measurement platforms against a true "gold standard," but what is that gold standard? Mass spectrometry? I'm not convinced.
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