Hosam Zaki

Reproductive medicine, Ganin Fertility Center
  • Ganin Fertility Center
  • Egypt

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Recent Comments

Feb 12, 2022

This study has the following points of concern:
1- The study excluded cases where BCL6 testing is very much needed such as women with >1 prior failed IVF, history of recurrent pregnancy loss, rather poor ovarian reserve. These are cases that BCL6 testing is suggested to be indicated

2- The result of positive BCL6 may be seen in the presence of inflammatory conditions such as endometriosis or hydrosalpinges (tubal condition). This study (as stated in table 3) has found significant (26.7% vs 2.9%) tubal factor in BCL6 positive cases, which explains the presence of live births in BCL6 positive cases, and that undermines the real value of BCL6 testing as a biological marker for endometriosis and it’s negative effect on live birth rates

3- The study did not look at essential other risk factors that form a crucial part in the diagnosis of endometriosis, such as symptoms (menstrual irregularities, deep dyspareunia, etc.) or ultrasonographic features of endometrioma or adenomyosis. Hence the findings of this study may be strictly applied when BCL6 is used as a screening test

Feb 12, 2022

This study has the following points of concern:
1- The study excluded cases where BCL6 testing is very much needed such as women with >1 prior failed IVF, history of recurrent pregnancy loss, rather poor ovarian reserve. These are cases that BCL6 testing is suggested to be indicated

2- The result of positive BCL6 may be seen in the presence of inflammatory conditions such as endometriosis or hydrosalpinges (tubal condition). This study (as stated in table 3) has found significant (26.7% vs 2.9%) tubal factor in BCL6 positive cases, which explains the presence of live births in BCL6 positive cases, and that undermines the real value of BCL6 testing as a biological marker for endometriosis and it’s negative effect on live birth rates

3- The study did not look at essential other risk factors that form a crucial part in the diagnosis of endometriosis, such as symptoms (menstrual irregularities, deep dyspareunia, etc.) or ultrasonographic features of endometrioma or adenomyosis. Hence the findings of this study may be strictly applied when BCL6 is used as a screening test

May 16, 2021

Did Coopersurgical use PGT-Ai (artificial intelligence) in the interpretation of the results, and would that attribute to the high variability of mosaicism rate in between  contributing centers?

Dec 16, 2019

This is a very interesting study for a very hot topics, however the study design was incomplete to give a definite answer for the following reasons:

1- defining exactly which embryos are eligible for biopsy, as there are many embryos were biopsied with less than grade 4 expansion. Also many embryos were of “C” grading. There is ample evidence that the time of biopsy and grade are crucial.
2- The percentage of good quality embryos were higher in the control group, and there was no comparison between equal quality embryos transferred.

3- there is no homogenousity  in-between centers with 85% of the centers done less than 30 samples. There was also wide variations with the percentage of euploid levels. That might reflect that “small contributing centers may be were still in the beginning of the learning curve at the time of study!

4- There was no unification in the definition what exactly considered as EUPLOID embryo, as some would consider less than 50% mosaicism as euploid, with some research showing significant difference between implantation rate of euploid embryo and mosaic with less than 50% aneuploidy cells.

Hence, I would not reach the same conclusion of the authors with the above issues.

Dr Hosam Zaki FRCOG
Ganin Fertility Center
Cairo Egypt