Pandiyan Natarajan

Andrology and Reproductive Medicine, Chettinad Super Speciality Hospital ( Retired) , Apollo 24/7, NOVA IVF FERTILITY
  • Chettinad Super Speciality Hospital ( Retired) , Apollo 24/7, NOVA IVF FERTILITY
  • India

About Pandiyan Natarajan

Andrology and Reproductive Medicine - 36 years experience.

Professor of Andrology and Reproductive Medicine and Chief Consultant in Andrology and Reproductive Medicine. (Retired)

Chettinad Super Speciality Hospital,

Chettinad Academy of Research and Education,

Kelambakkam, Chennai,

Tamil Nadu, India- 603103.

Recent Comments

Nov 27, 2022

Ethics always lags behind Technologies.

i enjoyed reading the article on Embryo Donation. It has raised many valid issues. 

The world at large is mostly comfortable with Heterosexual married couple Reproduction. Ethical objections are being raised regarding all non conventional Reproduction like single motherhood  with Insemination or single fatherhood with surrogacy and Third Party Reproduction. Embryo donation is a further step forward and results in Four party Reproduction. Embryo Adoption I feel is a more appropriate word. Quarantining the Embryo and rechecking the donor parents is almost never done.

Embryos are potential human beings. It would be a lot more ethical to encourage Embryo Donation rather than Destruction of the Embryo. All Embryos with unreachable parents should be the responsibility of the Government as is being done for Abandoned babies. The Government in turn should encourage Adoption of these embryos by some suitable couples following the same norm as in Adoption. This would relieve the burden of Infertility in many couples. 

Professor Dr Pandiyan Natarajan.

Chief Consultant in Andrology and Reproductive Sciences,

Apollo 24/7, NOVA IVF FERTILITY,

Chettinad Super Speciality Hospital (Retired)

Professor Emeritus, The Tamil Nadu Dr MGR Medical University.

Nov 09, 2022

We need Andrology - A- to replace E- Endocrinology in REI.

Infertility is a couple problem.  A competent practitioner of Infertility should have good working knowledge of Male and Female Infertility. Unfortunately, the experience and exposure of most of the Fellows in Reproductive Endocrinology and Infertility to Reproductive Andrology is very limited. It is essential that REI Fellows are trained in Reproductive Andrology. They must be trained in clinical evaluation of an Infertile male, relevant investigations and Spermatozoa Retrieval Techniques, if not in surgical correction of Obstructive Azoospermia  

Therefore, I feel REI should be RAI- Reproductive Andrology and Infertility.  All our Fellows are trained in Andrology and Reproductive Sciences and take care of the couple as a unit

Professor Dr Pandiyan Natarajan.

Chief Consultant in Andrology and Reproductive Sciences,

Apollo 24/7, NOVA IVF FERTILITY,

Chettinad Super Speciality Hospital (Retired)

Professor Emeritus, The Tamil Nadu Dr MGR Medical University.

Nov 09, 2022

We need Andrology - A- to replace E- Endocrinology in REI.

Infertility is a couple problem.  A competent practitioner of Infertility should have good working knowledge of Male and Female Infertility. Unfortunately, the experience and exposure of most of the Fellows in Reproductive Endocrinology and Infertility to Reproductive Andrology is very limited. It is essential that REI Fellows are trained in Reproductive Andrology. They must be trained in clinical evaluation of an Infertile male, relevant investigations and Spermatozoa Retrieval Techniques, if not in surgical correction of Obstructive Azoospermia  

Therefore, I feel REI should be RAI- Reproductive Andrology and Infertility.  All our Fellows are trained in Andrology and Reproductive Sciences and take care of the couple as a unit

Professor Dr Pandiyan Natarajan.

Chief Consultant in Andrology and Reproductive Sciences,

Apollo 24/7, NOVA IVF FERTILITY,

Chettinad Super Speciality Hospital (Retired)

Professor Emeritus, The Tamil Nadu Dr MGR Medical University.

Oct 31, 2022

Isn’t it time to stop doing Endometrial Receptivity Array?

Endometrium, is a dynamic tissue, it is  in constant dialogue with the Embryo. It  regenerates from the basal endometrium in every cycle. It was surprising that ERA proposed that receptivity estimate done in one cycle, even if correct will hold for future cycles. The hypothesis is based on wrong assumption.

Clinical studies have proven the futility of this cumbersome test. It is time the Test is given a decent burial. Though Endometrium plays an important role in implantation, it is still a secondary role. In the debate, ‘ Seed versus Soil,’ it is the seed which is the most important determinant of success.(1)

1. Does the endometrial thickness really matter in Assisted Reproductive
Technology Cycles - A Retrospective analysis
Gayathri Devi SS , N. Pandiyan, Radha Pandiyan                                                                                                              Chettinad Health City Medical Journal 2016; 5(1): 13 - 19   https://www.chcmj.ac.in/pdf/vol5_no1/Does_the_endometrial.pdf

Professor Dr Pandiyan Natarajan.

Chief Consultant in Andrology and Reproductive Sciences,

Apollo 24/7, NOVA IVF FERTILITY,

Chettinad Super Speciality Hospital (Retired)

Professor Emeritus, The Tamil Nadu Dr MGR Medical Unive

Comment on Who follows WHO?
Oct 28, 2022

Why to Follow WHO and what to follow in WHO semen analysis manual?

The introduction of WHO manual in 1980, brought in the much needed clarity to a confused Semen analysis picture and introduced standardized methods for evaluating a semen sample. However the so called Normal values mentioned in the first 4 volumes was far removed from reality. These values were based on Consensus, which unfortunately is an inappropriate way of doing science.

The numerical values given in the WHO manual - 6th edition may not be applicable to a given population. They are based on 5th percentile values in a certain fertile population. These values were based on single semen sample which as most of us know is notoriously unreliable. 

Following the Reference values given in the manual may not be suitable to all the populations. As was emphasized in the earlier manuals we need to estimate the basic semen analysis parameters and derive at the Reference values for our population.  To obtain uniformity in evaluating the semen sample, the standard methodology described in the WHO manual may be followed.

Professor Dr Pandiyan Natarajan.

Chief Consultant in Andrology and Reproductive Sciences,

Apollo 24/7, NOVA IVF FERTILITY,

Chettinad Super Speciality Hospital (Retired)

Professor Emeritus, The Tamil Nadu Dr MGR Medical University.

Oct 26, 2022

Poor quality embryos seem to increase the implantation rate.

The article made interesting reading.

The increase in multiple pregnancy rate and multiple birth rate without any increase in clinical pregnancy rate clearly suggests that the so called, ‘Poor quality embryos,’ are also capable of implantation and Live births.’

This paper raises an important question about the wisdom of discarding poor quality embryos. After all the judgement Poor quality is based on visual criteria and is prone for subjective error. At the best, it is still like, ‘ judging a book by its cover,’  and this has significant deficiencies. 

Professor Dr Pandiyan Natarajan.

Chief Consultant in Andrology and Reproductive Sciences,

Apollo 24/7, NOVA IVF FERTILITY,

Chettinad Super Speciality Hospital (Retired)

Professor Emeritus, The Tamil Nadu Dr MGR Medical University.

Oct 11, 2022
Preimplantation genetic testing for polygenic disease should be offered to- NONE.

Polygenic disease is a nebulous term. The term was introduced to explain conditions like Type 2 Diabetes Mellitus & Hypertension which run in families with no clearly discernible single gene defect. We forget that in all these conditions Epigenetic Factors play a bigger role compared to Genetics.

Preimplantation Genetic Testing for Aneuploidy is in a quandary. At this stage to introduce PGT for polygenic disease would create a brouhaha and considerable harm to the couple and the embryo.

Preimplantation genetic testing for polygenic disease should be offered to- NONE.

Professor Dr Pandiyan Natarajan,

Chief Consultant in Andrology and Reproductive Sciences,

Apollo 24/7, NOVA IVF FERTILITY,

Chettinad Super Speciality Hospital ( Retired )

Professor Emeritus, The Tamil Nadu Dr MGR Medical University.

Oct 09, 2022

Endometrial Receptivity Array- Dead on Arrival. Awaiting Obituary.

Endometrium, a dynamic tissue, in constant dialogue with the Embryo  regenerates from the basal endometrium in every cycle. It was surprising that ERA proposed that receptivity estimate done in one cycle even if correct will hold for future cycles. The hypothesis is based on a wrong assumption.

Clinical studies have proven the futility of this cumbersome test. It is time the Test is given a decent burial. Though Endometrium plays an important role in implantation, it is still a secondary role. In the debate, ‘ Seed versus Soil,’ it is the seed which is the most important determinant of success.(1)

1. Does the endometrial thickness really matter in Assisted Reproductive
Technology Cycles - A Retrospective analysis
Gayathri Devi SS , N. Pandiyan, Radha Pandiyan                                                                                                              Chettinad Health City Medical Journal 2016; 5(1): 13 - 19   https://www.chcmj.ac.in/pdf/vol5_no1/Does_the_endometrial.pdf

Professor Dr Pandiyan Natarajan.

Chief Consultant in Andrology and Reproductive Sciences,

Apollo 24/7, NOVA IVF FERTILITY,

Chettinad Super Speciality Hospital (Retired)

Professor Emeritus, The Tamil Nadu Dr MGR Medical University.

Details