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Aug 11, 2017
Replying to Jason Franasiak

Thank you for this very interesting and well done randomized controlled trial which evaluates culture conditions. It appears the findings strongly support. As noted in your manuscript, it appears as though the osmolality of the media changed despite oil overlay in the non-humid conditions. Are there other possible mechanism which could be impacted? Is there any thought that there might be an optimal humidity range for culture (rather than humid versus not) as an area for further study?

Jason, thank you for your comment. The other possible mechanisms may include a role for humidity to facilitate gases exchange and hence the micro environment stability. However, these are assumptions to be examined. The optimal humidity level is to be also specified. However, there is data from David McCulloh to subbort better clinical outcomes post IVF when the humidity increased to 99% compared to lower levels than 85%.