Proinflammatory cytokines induced altered expression of cyclooxygenase-2 gene results in unreceptive endometrium in women with idiopathic recurrent spontaneous miscarriage

Aberrant expression of proinflammatory, anti-inflammatory, and angiogenic cytokines alters the endometrial milieu, affecting the endometrial development and receptivity during implantation window in women with idiopathic recurrent spontaneous miscarriage.

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Authors

Priyanka Banerjee, M.Sc., Saikat Kumar Jana, M.Sc., Pallavi Pasricha, M.B.B.S, Sanghamitra Ghosh, M.B.B.S, Baidyanath Chakravarty, M.D., F.R.C.O.G., Koel Chaudhury, Ph.D.

Volume 99, Issue 1, Pages 179-187.e2, January 2013

Abstract

Objective:

To investigate the expression pattern of pro- and anti-inflammatory and angiogenic cytokines and their effect on various mediators of endometrial receptivity in women with idiopathic recurrent spontaneous miscarriage (IRSM) for understanding the basis of the disorder.

Design:

A prospective study.

Settings:

Tertiary care hospital and reproductive health research unit.

Patient(s):

Thirty-six women with IRSM (<35 years) and 30 fertile women as controls matched by age and body mass index undergoing sterilization. Intervention(s):

Endometrial biopsies in all women corresponding to the window of implantation.

Main Outcome Measure(s):

Assessment of endometrial expression of proinflammatory, anti-inflammatory, and angiogenic cytokines, mediators of matrix turnover and angiogenesis, markers of receptivity.

Results:

A statistical significantly higher level of proinflammatory cytokines, mediators of matrix turnover and angiogenesis, and a reduced expression of anti-inflammatory and angiogenic cytokines were observed in women with IRSM. Additionally, the markers of endometrial receptivity were poorly expressed in women with IRSM.

Conclusions:

Aberrant expression of pro-, anti-inflammatory, and angiogenic cytokines during implantation window in women with IRSM is one of the key factors which adversely affect endometrial development as evidenced by inadequate expression of various endometrial receptivity markers.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)02122-X/fulltext


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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