Role of decreased androgens in the ovarian response to stimulation in older women

As decreased ovarian testosterone production with age may compromise ovarian stimulation, we review maneuvers aimed at increasing ovarian testosterone and the likely potentiating effects of insulin-like growth factor I.

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Authors

David R. Meldrum, M.D., R. Jeffrey Chang, M.D., Linda C. Giudice, M.D., Ph.D., Juan Balasch, M.D., Robert L. Barbieri, M.D.

Volume 99, Issue 1, Pages 5-11, January 2013

Abstract

Ovarian testosterone increases antral follicles and their response to stimulation, it declines with age, and its effects are mediated or potentiated by insulin-like growth hormone-I (IGF-I). Increased circulating insulin and IGF-1, exogenous testosterone, and increased local ovarian testosterone concentrations due to aromatase inhibition or exogenous LH/hCG are all associated with an increased ovarian response to gonadotropins. These factors should be further investigated alone or in combination for enhancing oocyte yield with fertility treatments, particularly in older reproductive age women.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)02311-4/fulltext


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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