Live birth after transplantation of frozen-thawed ovarian tissue after bilateral oophorectomy for benign disease

Ovarian function was restored and pregnancy achieved in a woman who had previously undergone bilateral oophorectomy for benign disease and in whom frozen-thawed ovarian cortex was subsequently autotransplanted.

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Authors

Jacques Donnez, M.D., Ph.D., Pascale Jadoul, M.D., Céline Pirard, M.D., Ph.D., Graham Hutchings, M.D., Ph.D., Dominique Demylle, Ph.D., Jean Squifflet, M.D., Ph.D., Johan Smitz, M.D., Ph.D., Marie-Madeleine Dolmans, M.D., Ph.D.

Vol 98, Issue 3, Pages 720-725

Abstract

Objective:

To report restoration of ovarian function and pregnancy in a woman after bilateral oophorectomy for benign disease following autotransplantation of cryopreserved ovarian cortex.

Design:

Case report.

Setting:

Gynecology research unit in a university hospital.

Patient:

A 28-year-old woman who underwent bilateral adnexectomy for ovarian abscesses at the age of 18 years.

Intervention(s):

We performed ovarian cortex autotransplantation to a peritoneal pocket in the broad ligament.

Main Outcome Measure(s):

Restoration of ovarian activity and pregnancy.

Result(s):

Restoration of ovarian function began at 20 weeks and was achieved 24 weeks after transplantation. After the fifth stimulation attempt, 2 mature oocytes were obtained and microinjected. One embryo (7 cells) was obtained and transferred, leading to a normal pregnancy. The patient delivered a healthy baby boy weighing 2370g at 38 weeks of gestation.

Conclusion(s):

Ovarian cortex cryopreservation can be performed at the time of surgery for benign diseases when fertility is impaired. We report the first pregnancy to occur after ovarian tissue cryopreservation for benign ovarian pathology following bilateral oophorectomy.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00571-7/fulltext


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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