Preterm delivery and low birth weight in singleton pregnancies conceived by women with and without a history of infertility

Nulliparous women and women with a history of infertility who conceive a singleton after infertility treatment may be at increased risk for having a low-birthweight infant.

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Authors

Loretta Camarano, Ph.D., R.N.C., Abbey Alkon, Ph.D., P.N.P., Robert D. Nachtigall, M.D., Michael Schembri, M.S., Sandra Weiss, Ph.D., D.N.Sc., Mary S. Croughan, Ph.D.

Vol 98, Issue 3, Pages 681-686.e1

Abstract

Objective:

To determine predictors of low birth weight (LBW) and preterm delivery (PTD) in

singleton pregnancies conceived by women with and without a history of infertility.

Design:

Retrospective cohort study.

Setting:

Eleven infertility clinics in Northern California.

Patients:

Three groups of women who carried singleton pregnancies to ≥ 20 weeks gestation: 542 infertile women who conceived after treatment, 441 infertile women who conceived spontaneously, and 1008 fertile women for comparison.

Interventions:

Chart review.

Main Outcome Measures:

Association of LBW or PTD with infertility treatment, maternal age, parity, obesity, or development of gestational diabetes.

Results:

Infertile women who conceived with treatment were more likely to be obese, develop gestational diabetes, and have ovarian, ovulatory, or male factor infertility than infertile women who conceived spontaneously. Infertile women who conceived after treatment had 1.61 (95% CI 1.08– 2.41) times greater odds of having a LBW infant. Nulliparity was an independent predictor of LBW 1.54 (95% CI 1.09– 2.16) and PTD (OR 1.72, 95% CI 1.20-2.49) in all three groups after controlling for maternal age, history of infertility, infertility treatment, obesity, and gestational diabetes.

Conclusions:

Nulliparous women and women with a history of infertility who conceive a singleton after treatment may be at increased odds for having a LBW infant. Infertile women do not appear to be at increased odds for PTD.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00488-8/fulltext


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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