Comparison of two ready-to-use systems designed for sperm-hyaluronic acid binding selection before intracytoplasmic sperm injection: PICSI versus Sperm Slow: a prospective, randomized trial

PICSI and Sperm Slow allow comparable clinical efficiency in selecting HA-bound spermatozoa.

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Authors

Lodovico Parmegiani, M.Sc., Graciela Estela Cognigni, M.D., Silvia Bernardi, B.Sc, Enzo Troilo, B.Sc., Stefania Taraborrelli, M.D., Alessandra Arnone, B.Sc., Antonio Manuel Maccarini, B.Sc., Marco Filicori, M.D.

Vol 98, Issue 3, Pages 632-637

Abstract

Objective:

To compare in a strict randomized way the efficiency of two ready-to-use systems for hyaluronic acid (HA)-ICSI: an HA culture dish (PICSI Sperm Selection Device), and a viscous medium containing HA (Sperm Slow).

Design:

Prospective, randomized study

Setting:

GynePro Medical Centers, Bologna, Italy

Patient(s):

50 subjects per treatment group (100 total)

Intervention(s):

100 ICSI treatments randomly carried out with PICSI or with Sperm Slow for sperm selection. Randomization conducted with sealed envelopes. ICSI performed by a single embryologist with 5-year experience in HA-ICSI.

Mean outcome measure(s):

Primary outcome measure: good-quality embryo rate.

Secondary outcome measures:

Oocyte fertilization, pregnancy and implantation rate, and the duration of the ICSI procedure.

Result(s):

Good quality embryo rate comparable between the two groups (58,5% PICSI® versus 56% Sperm Slow™ – P=0.691). Overall, no statistically significant differences in secondary outcome measures except ICSI procedure duration, which was 3 minutes longer (P≤0.001) in the PICSI® group.

Conclusion(s):

Both PICSI® and Sperm Slow™ allow comparable clinical efficiency in selecting HA-bound spermatozoa.

Clinical Trials Registration number:

ISRCTN72668039

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00597-3/fulltext


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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