Subtle progesterone rise on the day of hCG administration is associated with lower live birth rates in women undergoing assisted reproductive technology: a retrospective study with 2,555 fresh embryo transfers

In this retrospective, observational, cohort study with 2,555 women, a rise of serum P levels on the day of hCG administration was associated with a reduced live birth rate after day-5 fresh ET.

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Authors

Robert Ochsenkühn, M.D., Andrea Arzberger, M.D., Viktoria von Schönfeldt, Ph.D., Julia Gallwas, M.D., Nina Rogenhofer, M.D., Alexander Crispin, M.D., Christian J. Thaler, M.D., Ulrich Noss, M.D.

Vol 98, Issue 2 , Pages 347-354

Abstract

Objective:

To evaluate the association between serum P levels on the day of hCG administration and pregnancy outcome in women undergoing controlled ovarian hyperstimulation, prevention of premature ovulation by GnRH analogues, and fresh ET after 5 days of embryo culture.

Design:

Retrospective, observational, cohort study.

Setting:

Private IVF center.

Patient(s):

A total of 2,555 women undergoing fresh ET on day 5 in 2,062 GnRH agonist and 493 GnRH antagonist cycles.

Intervention(s):

None.

Main Outcome Measure(s):

Live birth rate.

Result(s):

Live birth rate in cycles with GnRH agonists was significantly lower in women with P levels ≥2.0 ng/mL (17.4%) on the day of hCG administration as compared with women with P levels

Conclusion(s):

A rise of serum P levels ≥2.0 ng/mL on the day of hCG administration is associated with impaired early embryo implantation and reduced live birth rate in cycles with GnRH agonists after day-5 fresh ET.

Clinical Trial Registration Number:

NCT01426152.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00496-7/fulltext


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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