Klinefelter Syndrome: How, What and Why?

This collection of articles written by a series of experts should help all those who deal with Klinefelter syndrome patients develop a much broader and scientifically based understanding of this common condition.

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Authors

Mark Sigman, M.D.

Vol 98, Issue 2, Pages 251-252

Abstract

Klinefelter syndrome is the most common genetic cause of male infertility. Prior to the advent of ICSI and the finding that sperm can be retrieved from the testes of approximately 50% of men with Klinefelter syndrome, these patients were referred for donor insemination or adoption as their only options. While it has now become routine that infertile Klinefelter patients are referred for consideration for ART, much remains unknown or controversial about this common syndrome. This Views and Reviews article explores the "How, What, and Why" of Klinefelter syndrome: How does it occur, what is the phenotype and natural history, and why take particular treatment approaches.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00548-1/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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