Cost-effectiveness of cytogenetic evaluation of products of conception in the patient with a second pregnancy loss

Genetic analysis of the products of conception may provide substantial net economic benefits in evaluation of recurrent pregnancy loss.

0
0

Authors

Nastaran Foyouzi, M.D., Marcelle I. Cedars, M.D., Heather G. Huddleston, M.D.

Vol 98, Issue 1 , Pages 151-155.e3

Abstract

Objective:

To compare the cost of two strategies for managing the patient with recurrent pregnancy loss (RPL).

Design:

Cost analysis using a decision analytic model was used to compare obtaining an evidence-based workup (EBW) for RPL versus obtaining a karyotype of the products of conception (POC) and proceeding with an EBW only in the setting of euploid POC.

Setting:

Outpatient care.

Patient(s):

A simulated cohort of patients experiencing a second pregnancy loss.

Intervention(s):

Not applicable.

Main Outcome Measure(s):

Total cost of investigating the cause of RPL after a second pregnancy loss.

Result(s):

For all age categories, obtaining a karyotype of POC was less costly than an evidenced-based RPL evaluation. Monte Caro analysis demonstrated a net economic benefit for the karyotype strategy ($4,498 [±$792] vs. $5,022 [±$1,130]).

Conclusion(s):

Our model suggests an economic advantage for obtaining a karyotype of POC in women with second miscarriage.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00438-4/fulltext


Go to the profile of Fertility and Sterility

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

No comments yet.