Reduced pretreatment ovarian reserve in premenopausal female patients with Hodgkin Lymphoma or Non-Hodgkin-Lymphoma – evaluation by using Anti-Muellerian hormone and retrieved oocytes

We discuss how ovarian reserve is already reduced in young female lymphoma patients before the start of chemotherapy.

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Authors

Barbara Lawrenz, M.D., Tanja Fehm, Ph.D., Michael von Wolff, Ph.D., Martin Soekler, M.D., Stephanie Huebner, M.D., Joerg Henes, M.D., Melanie Henes, M.D., Centers of the FertiPROTEKT Network

Vol 98, Issue 1 , Pages 141-144

Abstract

Objective:

To study whether the ovarian reserve in female lymphoma patients is already reduced before the start of chemotherapy.

Design:

Age-matched control study.

Setting:

Women's university hospital.

Patient(s):

Female patients aged

Intervention(s):

Measurement of antimüllerian-hormone (AMH) levels. Ovarian hormonal stimulation to retrieve oocytes.

Main Outcome Measure(s):

AMH levels of the lymphoma patients and the healthy volunteers were compared. Numbers of retrieved oocytes after hormonal stimulation in patients with breast cancer and those with lymphoma were compared.

Result(s):

Female lymphoma patients have significantly lower AMH levels than healthy age-matched controls: mean value of AMH was 2.06 ng/mL in the study group versus 3.20 ng/mL in the control group. Analysis of the stimulation results showed that in significantly younger patients with lymphoma, significantly fewer oocytes could be retrieved in comparison to those with breast cancer.

Conclusion(s):

Ovarian reserve is reduced in female patients affected by lymphoma even before the start of chemotherapy. Proper counseling and implementation of fertility-preserving methods is highly recommended.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00453-0/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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