Development and current applications of assisted fertilization

We describe the early steps that brought forth the development of intracytoplasmic sperm injection and its role in assisted reproduction techniques.

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Authors

Gianpiero D. Palermo, M.D., Ph.D., Queenie V. Neri, M.Sc., Devin Monahan, B.Sc., Justin Kocent, B.Sc., Zev Rosenwaks, M.D.

Volume 97, Issue 2 , Pages 248-259

Abstract

Since the very early establishment of in vitro insemination, it became clear that one of the limiting steps is the achievement of fertilization. Among the different assisted fertilization methods, intracytoplasmic sperm injection emerged as the ultimate technique to allow fertilization with ejaculated, epididymal, and testicular spermatozoa. This work describes the early steps that brought forth the development of intracytoplasmic sperm injection and its role in assisted reproductive techniques. The current methods to select the preferential male gamete will be elucidated and the concerns related to the offspring of severe male factor couples will be discussed.

Read the full text at: http://www.fertstert.org/article/S0015-0282(11)02921-9/fulltext

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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