Effect of body mass index on pregnancy outcomes with the freeze-all strategy in women with polycystic ovarian syndrome

An elevated body mass index has a statistically inverse association with the live birth rate in women with polycystic ovary syndrome with the freeze- all strategy.

0
0

Volume 112, Issue 6, Pages 1172–1179

Authors:

Meiting Qiu, M.D., Yu Tao, M.D., Ph.D., Yanping Kuang, M.D., Ph.D., Yun Wang, M.D., Ph.D.

Abstract:

Objective

To investigate the effects of body mass index (BMI) on assisted reproductive outcomes with the freeze-all strategy for patients with polycystic ovary syndrome (PCOS).

Design

Retrospective cohort study.

Setting

Tertiary care academic medical center.

Patient(s)

A total of 3,079 women with PCOS across different BMIs at our institution from January 2015 to May 2017 were stratified into cohorts.

Intervention(s)

None.

Main Outcome Measure(s)

Implantation rate, clinical pregnancy rate, early miscarriage rate, and live birth rate.

Result(s)

The live birth rate was most favorable in underweight (BMI < 18.5 kg/m2) and normal weight cohorts (18.5 ≤ BMI < 25 kg/m2) and progressively decreased as BMI increased. Moreover, the obese cohort (BMI ≥ 30 kg/m2) of patients with PCOS who had frozen ET cycles had a relatively high early miscarriage rate.

Conclusion(s)

The live birth rates are highest in underweight and normal weight patients with PCOS undergoing IVF with the freeze-all strategy. Furthermore, there is a progressive and statistically significant decrease in the live birth rate and an increase in the miscarriage rate in obese patients with PCOS.


Read the full text here.

Go to the profile of Fertility and Sterility

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

No comments yet.