Ovarian stimulation and assisted reproductive technology outcomes in women transplanted with cryopreserved ovarian tissue: a systematic review
Article In Press
Signe Taasti Andersen, B.Sc., Susanne Elisabeth Pors, Ph.D., Liv la Cour Poulsen, M.D., Lotte Berdiin Colmorn, M.D., Ph.D., Kirsten Tryde Macklon, M.D., Ph.D., Erik Ernst, M.D., Ph.D., Peter Humaidan, M.D., D.M.Sc., Claus Yding Andersen, D.M.Sc., Stine Gry Kristensen, Ph.D.
To systematically review reproductive outcomes of assisted reproductive technology (ART) treatment in women transplanted with frozen-thawed ovarian tissue.
Systematic review in accordance with guidelines from Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).
Women undergoing ovarian tissue transplantation (OTT) and subsequent ART.
Literature search in PubMed and Scopus databases.
Main Outcome Measure(s)
Time from OTT to initiation of ART, stimulation protocol, and conventional ART outcome measures.
Twenty studies (including 15 case reports), specifying ART treatments and outcomes of 40 women undergoing OTT were identified. Multiple stimulation protocols were applied, with the modified natural cycle as the most frequently used. In total, 195 ART cycles were performed (4.0 cycles per patient) resulting in 1.5 follicles and 1.0 mature oocyte retrieved per cycle. Empty follicle rates ranged from 23% to 35% in the three largest cohort studies. Twenty-five women (62.5%) had one or more pregnancies, of which 28.6% were lost, resulting in a total of 20 live births (22 children). Overall the pregnancy rates varied from 3.9% to 19.3% and live-birth rates from 3.9% to 14.0% per cycle in the three cohort studies. Fertility treatment was initiated shortly after OTT in some centers, while others awaited natural conception before embarking on ART treatment.
The reported pregnancy and live-birth rates for women undergoing OTT and ART were considerably lower than those of the general in vitro fertilization (IVF) population, corresponding to patients with poor ovarian reserve. In general, ART outcomes are underreported, and there is a lack of consensus regarding the timing of ART in relation to OTT and the type of ovarian stimulation protocol.