Impact of right–left differences in ovarian morphology on the ultrasound diagnosis of polycystic ovary syndrome

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Authors:

Brittany Y. Jarrett, Ph.D., Heidi Vanden Brink, M.Sc., Eric D. Brooks, M.D., Kathleen M. Hoeger, M.D., Steven D. Spandorfer, M.D., Roger A. Pierson, Ph.D., M.S., Donna R. Chizen, M.D., Marla E. Lujan, Ph.D., M.Sc.

Abstract:

Objective

To assess right–left differences in ultrasonographic markers of ovarian morphology and determine the impact on the diagnosis of polycystic ovarian morphology (PCOM).

Design

A cross-sectional study of data collected from 2006 to 2018.

Setting

Academic clinical research centers.

Patient(s)

Women with polycystic ovary syndrome (PCOS; n = 87) and controls (n = 67).

Intervention(s)

None.

Main Outcomes Measure(s)

Follicle number per ovary (FNPO), follicle number per cross-section (FNPS), and ovarian volume (OV) were assessed in both ovaries using transvaginal ultrasonography. PCOM was identified based on recent international consensus guidelines or proposed diagnostic thresholds.

Result(s)

Overall, mean right–left differences were two follicles for FNPO, one follicle for FNPS, and 2 mL for OV. FNPO showed the strongest correlation between ovaries. Its assessment in a single ovary did not impact the diagnosis of PCOM in women with PCOS. However, there were differences in the probability of unilateral versus bilateral PCOM based on FNPS and OV in both groups.

Conclusion(s)

FNPO is the most reliable unilateral marker of PCOM in light of right–left differences in ovarian morphology. Use of FNPS or OV to define PCOM is discouraged when only one ovary is visualized.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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