Benefits of pregnancy on endometriosis: can we dispel the myths?

Article In Press



Brigitte Leeners, M.D.a, Cynthia M. Farquhar, MB.Ch.B., M.D., M.P.H.b,c


Regression of endometriotic lesions during pregnancy was first described by Sampson in 1921. Since that time pregnancy has often been recommended by health professionals as a useful strategy to reduce disease progression and symptoms. Lack of symptoms before menarche and after menopause, both associated with amenorrhoea, further supported the hypothesis that pregnancy was beneficial. Progesterone induces endometrial atrophy and endometriotic lesions show cyclic changes such as endometrial growth and luteal transformation throughout the menstrual cycle.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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