The receptive endometrium: the thinner the better?

Article In Press

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Authors:

Eric J. Forman, M.D., H.C.L.D.

Abstract:

Reflections on "Endometrial compaction (decreased thickness) in response to progesterone results in optimal pregnancy outcome in frozen embryo transfers" by Haas et al.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

1 Comments

Robert F Casper 5 days ago

We are grateful to Dr Forman for his thoughtful comments. We agree with all the points he raises. In particular, we are now in the process of analyzing data from PGT-A tested single blastocyst transfers as he suggests to try to isolate the endometrial effect from embryo quality. We will be submitting this manuscript soon. We have also started a prospective study involving a vaginal ultrasound scan at the end of the estrogen phase and another vaginal ultrasound on day 4 of progesterone. In this study design, we will transfer embryos based on the estrogen phase scan as usual and we will be blinded to the day 4 scan until the end of the study. This study will address the weakness that Dr Forman raises concerning the comparison of a vaginal ultrasound with an abdominal scan before embryo transfer. In addition, if this study validates the results from our present study, a vaginal scan on day 4 of progesterone will allow cancellation of an FET cycle prior to thawing the embryo. We would then need to work on how to get the lining to compact in subsequent cycles.