Trends and correlates of the sex distribution among U.S. assisted reproductive technology births

The sex distribution of live-born infants from pregnancies achieved through assisted reproductive technology can vary by use of preimplantation genetic diagnosis/preimplantation genetic screening, use of intracytoplasmic sperm injection, embryo stage at transfer, and number of embryos transferred.

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Volume 112, Issue 2, Pages 305–314

Authors:

Jennifer L. Narvaez, M.D., Jeani Chang, Ph.D., M.P.H., Sheree L. Boulet, Dr.P.H., M.P.H., Michael J. Davies, Ph.D., M.P.H., Dmitry M. Kissin, M.D., M.P.H.

Abstract:

Objective

To assess national trends in the sex distribution of live-born infants in the assisted reproductive technology (ART) and general population and to identify factors correlated with offspring sex.

Design

Retrospective cohort study.

Setting

Fertility treatment centers.

Patients

All live-born infants included in the National Vital Statistics System and resulting from ART cycles reported to the National ART Surveillance System during 2006–14.

Interventions

Not applicable.

Main Outcome Measure(s)

Trends in the proportion of male infants in the general population and proportion of males from fresh ART cycles among all ART live-born infants and singletons after single ET.

Result(s)

There were 214,274 live-born infants resulting from fresh ART cycles; 53.5% (5,492/10,266) of infants resulting from PGD/PGS cycles were male, as compared with 50.6% (103,228/204,008) in the non-PGD/PGS group. Among non-PGD/PGS cycles, blastocyst transfer was positively associated with male infants (adjusted risk ratio [aRR] = 1.03; 95% confidence interval [CI], 1.02–1.04). Intracytoplasmic sperm injection was negatively associated with male infants (aRR = 0.94; 95% CI, 0.93–0.95) and for singletons after single ET (aRR = 0.93; 95% CI, 0.90–0.95), as was transfer of two embryos (aRR 0.98; 95% CI, 0.97–0.99) or three or more embryos (aRR = 0.98; 95% CI, 0.96–0.99) among all live births from cycles without PGD/PGS use.

Conclusion(s)

The proportion of male live-born infants among ART population did not change during 2006–14, ranging from 50.5% to 51.2%. Factors such as blastocyst transfer, intracytoplasmic sperm injection use, embryo stage, and number of embryos transferred may be associated with infant sex; further investigation is needed to understand possible underlying causes.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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