Impact of female daily coffee consumption on successful fertility treatment: a Danish cohort study

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Authors:

Julie Lyngsø, M.D., Ulrik Schiøler Kesmodel, Ph.D., Bjørn Bay, Ph.D., Hans Jakob Ingerslev, D.M.Sc., Anne-Marie Nybo Andersen, Ph.D., Cecilia Høst Ramlau-Hansen, Ph.D.

Abstract:

Objective

To investigate whether female coffee consumption affects the chance of achieving a clinical pregnancy and a live birth among women and couples receiving medically assisted reproduction (MAR) treatment.

Design

Cohort study with prospectively collected exposure data.

Setting

Public fertility clinic.

Patient(s)

A total of 1,708 women and potential partners undergoing fertility treatment, contributing with 1,511 intrauterine insemination (IUI) cycles, 2,870 in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles, and 1,355 frozen embryo transfer cycles.

Intervention(s)

None.

Main Outcome Measure(s)

Clinical pregnancy and live birth in consecutive treatment cycles in the Danish national health registries, enabling complete follow-up, and estimation of the cumulative chance of live birth for three consecutive treatment cycles.

Result(s)

Among women receiving IVF or ICSI treatment, coffee consumption did not seem to affect the chance of achieving a clinical pregnancy and a live birth. Women treated with IUI who had a daily coffee consumption of 1–5 cups were more likely to achieve a clinical pregnancy (adjusted relative risk 1.49; 95% confidence interval, 1.05–2.11) and live birth (adjusted relative risk 1.53; 95% confidence interval, 1.06–2.21) compared with the reference group of coffee abstainers.

Conclusion(s)

Women consuming 1–5 cups versus none had a 1.5-fold higher probability of achieving a pregnancy or a live birth when receiving IUI. No associations were found, however, between women's daily coffee consumption and achieving a pregnancy or a live birth from IVF/ICSI.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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