Health of adults aged 22 to 35 years conceived by assisted reproductive technology

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Authors:

Jane Halliday, Ph.D., Sharon Lewis, Ph.D., Joanne Kennedy, M.G.C., David P. Burgner, Ph.D., Markus Juonala, Ph.D., Karin Hammarberg, Ph.D., David J. Amor, Ph.D., Lex W. Doyle, M.D., Richard Saffery, Ph.D., Sarath Ranganathan, Ph.D., Liam Welsh, Ph.D., Michael Cheung, Ph.D., John McBain, M.D., Stephen J.C. Hearps, Ph.D., Robert McLachlan, Ph.D.

Abstract:

Objective

To determine the health outcomes for adults aged 22–35 years old who were conceived via assisted reproduction technology (ART) compared with adults of the same age conceived without use of ART.

Design

Cohort study.

Setting

Not applicable.

Patient(s)

Adult men and women aged 22–35 years who were conceived with and without use of ART.

Intervention(s)

Questionnaire and clinical review.

Main Outcome Measure(s)

Vascular structure (carotid artery intima-media thickness, pulse wave velocity), vascular function (blood pressure), metabolic markers (fasting blood glucose, insulin, and standard lipid profiles), anthropometric measurements, and respiratory function (spirometry).

Result(s)

The mean age of the 193 ART and 86 non-ART participants was 27.0 and 26.9 years, respectively. There were no substantial intragroup differences in demographics or vascular intermediate phenotypes, metabolic parameters, or anthropometric measures, before or after adjusting for perinatal factors and a quality of life measure with four domains. Diastolic blood pressure was lower in the ART men than the non-ART men (adjusted mean difference −4.4 mm Hg, 95% CI, −8.7 to −0.1). The ART group reported a higher prevalence of ever having asthma, (40.8% vs. 28.6%; odds ratio 1.7; 95% CI, 1.0–3.0), but expiratory flow rates were similar.

Conclusion(s)

This study of the health of 193 adults conceived via ART, the largest to date globally, found no evidence of increased vascular or cardiometabolic risk, or growth or respiratory problems in the ART group compared with a non-ART group from the same source population. Follow-up observation for reproductive and later-onset adverse health effects remains important.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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