Cost-effectiveness of preimplantation genetic testing for aneuploidies

The use of preimplantation genetic testing for aneuploidies is highly debated. This theoretical study suggests that the procedure can be economically advantageous when used in specific settings and patient groups.

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Volume 111, Issue 6, Pages 1169–1176

Authors:

Edgardo Somigliana, M.D., Ph.D., Andrea Busnelli, M.D., Alessio Paffoni, M.Sc., Ph.D., Paola Vigano, M.Sc., Ph.D., Alessandra Riccaboni, M.D., Carmen Rubio, M.Sc., Antonio Capalbo, M.Sc.

Abstract:

Objective

To evaluate the economical benefit of preimplantation genetic testing of aneuploidies (PGT-A) when applied in an extended culture and stringent elective single ET framework.

Design

Theoretical cost-effectiveness study.

Setting

Not applicable.

Patients/Animal(s)

None.

Intervention(s)

Comparison of the cost-effectiveness between two IVF treatment strategies: serial transfer of all available blastocysts without genetic testing (first fresh transfer and subsequent frozen-thawed transfer); and systematic use of genetic testing (trophectoderm biopsy, freeze-all, and frozen-thawed transfers of euploid blastocysts). The costs considered for this analysis are based on regional public health system provider.

Main Outcome Measure(s)

Costs per live birth.

Result(s)

Cost-effectiveness profile of PGT-A improves with female age and number of available blastocysts. Sensitivity analyses varying the costs of ET, the costs of genetic analyses, the magnitude of the detrimental impact of PGT-A on live birth rate, and the crude live birth rates change to some extent the thresholds for effectiveness but generally confirm the notion that PGT-A can be economically advantageous in some specific subgroups.

Conclusion(s)

PGT-A can be cost-effective in specific clinical settings and population groups. Economic considerations deserve attention in the debate regarding the clinical utility of PGT-A.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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