Serum antimüllerian hormone concentration increases with ovarian endometrioma size

Article In Press



Louis Marcellin, M.D., Ph.D., Pietro Santulli, M.D., Ph.D., Mathilde Bourdon, M.D., Clémence Comte, M.D., Chloé Maignien, M.D., Pierre Alexandre Just, M.D., Ph.D., Isabelle Streuli, M.D., Ph.D., Bruno Borghese, M.D., Ph.D., Charles Chapron, M.D.



To examine whether serum antimüllerian hormone (AMH) levels correlate with the size of ovarian endometrioma (OMA).


An observational cross-sectional study.


A university hospital.


Two hundred and sixty-seven nonpregnant women, aged 18–42 years, with no prior history of surgery for endometriosis and a histologically documented ovarian cyst.


Surgical management for a benign ovarian cyst.

Main Outcome Measure(s)

Correlation between serum AMH concentration and cyst size according to OMA and non-OMA benign cyst.


Women with OMA were compared with a control group of women who had non-OMA benign ovarian cysts. The AMH assay samples were collected less than a month before the surgery. Between January 2004 and September 2016, 148 women were allocated to the OMA group and 119 to the non-OMA benign cyst group. The AMH concentrations were not statistically significantly different between the two groups (3.7 ± 2.8 ng/mL vs. 4.1 ± 3.3 ng/mL). A multiple linear regression model accounting for potential confounders revealed that the log10 of the serum AMH concentration positively correlated with the log10 of the OMA cyst volume (R2 = 0.23; coefficient = 0.05; 95% CI, 0.007–0.10).


In women no prior history of surgery for endometriosis, serum AMH levels increased with cyst size in cases of OMA.

Read the full text here.

Go to the profile of Fertility and Sterility

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

No comments yet.