Prewash total motile count is a poor predictor of live birth in intrauterine insemination cycles

Prewash total motile count is a poor predictor of live birth in IUI cycles. Women older than 37 years have a decreased live birth rate with IUI.

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Volume 111, Issue 4, Pages 708–713

Authors:

Erin B. Mankus, M.D., Alan E. Holden, Ph.D., Paige M. Seeker, M.D., Jordan C. Kampschmidt, B.A., Jessica E. McLaughlin, M.D., Robert S. Schenken, M.D., Jennifer F. Knudtson, M.D.

Abstract:

Objective

To determine whether there is a relationship between prewash total motile count and live births in couples undergoing IUI.

Design

Retrospective review in a single academic center.

Setting

Not applicable.

Patient(s)

Couples with infertility undergoing ovulation induction with IUI between 2010 and 2014.

Intervention(s)

Not applicable.

Main Outcome Measure(s)

Live births.

Result(s)

Our cohort included 310 women who underwent 655 IUI cycles with a cumulative live birth rate (LBR) per couple of 20% and an LBR per cycle of 10%. A analysis yielded no correlation between prewash total motile count (TMC) and live births. No live births occurred with TMC <2 million sperms. Age had a significant negative relationship to LBR. A receiver operating characteristic analysis comparing age and live births indicated a significant decline in live births for women >37 years (90% sensitivity, 70% specificity). The LBR per couple was decreased to 7% in women >37 years compared with 25% in women <37 years.

Conclusion(s)

Prewash TMC is a poor predictor of live birth. There were no live births with prewash TMC <2 million sperms. The LBR for women >37 years with IUI was significantly lower than women <37 years.


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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