Surgical outcomes after uterine artery occlusion at the time of myomectomy: systematic review and meta-analysis

Uterine artery occlusion at myomectomy is associated with decreased intraoperative blood loss, hemoglobin change, and transfusion rate compared with controls and is a safe, effective intervention to reduce blood loss.

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Volume 111, Issue 4, Pages 816–827.e4

Authors:

Ari P. Sanders, M.D., Wilson V. Chan, M.D., M.Sc., Jennifer Tang, H.B.Sc., Ally Murji, M.D., M.P.H.

Abstract:

Objective

To systematically review and meta-analyze evidence on surgical outcomes after uterine artery occlusion (UAO) at myomectomy.

Design

Systematic review and meta-analysis.

Setting

Not applicable.

Patient(s)

Twenty-six studies involving 2,871 patients located via database searches of MEDLINE, Embase, Web of Science, PubMed, clinicaltrials.gov, and cited references.

Intervention(s)

Intervention groups undergoing UAO at laparoscopic or abdominal myomectomy (UAO+M) (1,569 patients), and control groups undergoing myomectomy alone (1,302 patients).

Main Outcome Measure(s)

Primary outcome of surgical blood loss (estimated blood loss, transfusion rate, and change in hemoglobin values), and secondary outcomes including operative time, length of stay, conversion and complications rates, fibroid recurrence, and changes in fibroid-related symptoms.

Result(s)

The patients undergoing UAO+M had a statistically significant reduction in estimated blood loss (mean difference [MD] −103.7 mL; 95% confidence interval [CI], −126.5 to −80.8), blood transfusion (relative risk [RR] 0.24; 95% CI, 0.15–0.39), and change in hemoglobin values (MD −0.60 g/dL; 95% CI, −0.79 to −0.40) compared with controls. Using UAO+M prolonged operative times (MD 10.9 minutes; 95% CI, 3.5–18.2) but shortened the length of stay (MD −0.37 days; 95% CI, −0.62–0.11). Using UAO+M lowered the complication rates (RR 0.73; 95% CI, 0.52–1.00) to the threshold of statistical significance and reduced the risk of fibroid recurrence (RR 0.36; 95% CI, 0.16–0.83) compared with controls.

Conclusion(s)

Uterine artery occlusion at myomectomy is associated with decreased surgical blood loss and transfusion rate compared with control patients. However, further research is required on reproductive outcomes and the effect on ovarian reserve before routine use can be recommended in women desiring future fertility.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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