What if deep endometriotic nodules and uterine adenomyosis were actually two forms of the same disease?

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Jacques Donnez, M.D., Ph.D., Marie-Madeleine Dolmans, M.D., Ph.D., Latifa Fellah, M.D.


Some symptoms of endometriosis, such as severe dysmenorrhea, overlap with those of uterine adenomyosis, a disease characterized by growth of endometrium into the myometrium. From a histologic point of view, deep rectovaginal endometriotic nodules were described by Donnez et al. (1) back in 1996 as “adenomyomas,” consisting of smooth muscle hyperplasia with active glandular epithelium and scanty stroma. In fact, the histologic patterns of deep endometriosis and uterine adenomyosis appear to be very similar.

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