The impact of malignancy on response to ovarian stimulation for fertility preservation: a meta-analysis

Cancer diagnosis does not affect response to ovarian stimulation in women undergoing fertility preservation.

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Volume 110, Issue 7, Pages 1347–1355

Authors:

Volkan Turan, M.D., Molly M. Quinn, M.D., Nurten Dayioglu, Ph.D., Mitchell P. Rosen, M.D., Kutluk Oktay, M.D., Ph.D.

Abstract:

Objective

To evaluate the impact of cancer diagnosis on response to ovarian stimulation for fertility preservation.

Design

Meta-analysis.

Setting

Not applicable.

Patient(s)

An electronic-based search was performed with the use of PubMed until May 2018 limited to English-language articles. In the final analysis, 10 case-controlled retrospective cohort studies were included, comparing ovarian response to stimulation between women with cancer and age-matched healthy women (control group).

Intervention(s)

None.

Main outcome measure(s)

Number of total oocytes retrieved, number of mature oocytes, fertilization rate and two pronuclei embryos obtained.

Result(s)

Ten studies that included a total of 713 women with cancer were analyzed in the cancer group (722 cycles), and 1,830 healthy women (1,835 cycles) qualified as controls for the meta-analysis. The pooled results showed no impact of cancer diagnosis on the mean number of total oocytes (P=.517; 95% CI −0.23 to 0.12), mature oocytes (P=.104; 95% CI −0.23 to 0.01), and two pronuclei embryos (P=.136; 95% CI −0.32 to 0.04) and fertilization rates (P=.273; 95% CI −0.29 to 0.183). When the analysis was limited to women with breast cancer diagnosis, there was also no difference in the mean number of total oocytes (P=.812; 95% CI −0.28 to 0.36) and mature oocytes (P=.993; 95% CI −0.16 to 0.16) between the two groups.

Conclusion(s)

This meta-analysis indicates that cancer diagnosis is not associated with reduced response to ovarian stimulation.


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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