The impact of using donor sperm in assisted reproductive technology cycles on perinatal outcomes

The use of donor sperm in fresh autologous ART cycles was not associated with increased miscarriage, preterm births, or low birthweights, as compared to cycles using partner sperm.

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Volume 110, Issue 7, Pages 1285–1289

Authors:

Bo Yu, M.D., M.S., Rani Fritz, D.O., Ph.D. ∗, Xianhong Xie, Ph.D., Abdissa Negassa, Ph.D., Sangita Jindal, Ph.D., Mario Vega, M.D., Erkan Buyuk, M.D.

Abstract:

Objective

To assess the impact of using donor sperm in assisted reproductive technology (ART) cycles on perinatal outcomes.

Design

Historical cohort study.

Setting

US national database from the Society of Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) from 2012 to 2013.

Patient(s)

Patients undergoing the first fresh autologous ART cycle using either donor or partner sperm.

Intervention(s)

None.

Main Outcome Measure(s)

Miscarriage, preterm birth, low birthweight rates.

Results

A total of 134,710 fresh autologous ART cycles were evaluated from the SART CORS database. Following exclusion criteria and after restricting to the first cycle, 2,123 donor sperm and 42,799 partner sperm ART cycles were included in the final analyses. After adjusting for all confounding variables (including maternal age, race, body mass index, smoking status, gravidity, history of preterm birth, highest follicle stimulating hormone count, blastocyst transfer percentage, total embryo transferred, and etiology of infertility), no statistically significant differences in miscarriage rates, preterm births, very preterm births, low birthweight, and very low birthweight were observed. Birthweight was significantly lower in the partner sperm group than in the donor sperm group (3,292 ± 601 and 3,233 ± 592 g in donor and partner sperm groups, respectively, adjusted P value 0.003); however, this small absolute difference (adjusted effect estimate 42 g, 95% CI 14.7–70.9) does not carry clinical significance.

Conclusions

The use of donor sperm in fresh autologous ART cycles was not associated with increased miscarriage, preterm births, or low birthweights, as compared to cycles using partner sperm. This information can be used in patient counseling to reassure patients using donor sperm in ART cycles.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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