The pros and cons of preimplantation genetic testing for aneuploidy (PGT-A): clinical and laboratory perspectives

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Volume 110, Issue 3, Pages 353–361

Authors:

Zev Rosenwaks, M.D., Alan H. Handyside, Ph.D., Francesco Fiorentino, Ph.D., Norbert Gleicher, M.D., Richard J. Paulson, M.D., Glenn L. Schattman, M.D., Richard T. Scott Jr., M.D., Michael C. Summers, M.D., Ph.D., Nathan R. Treff, Ph.D., Kangpu Xu, Ph.D.

Abstract:

To contribute to a balanced debate, we invited leading proponents and opponents of preimplantation genetic testing for aneuploidy (PGT-A) to briefly summarize their arguments. Four contributors debate the pros and cons from a clinical perspective, two consider technical aspects related to the validation and accuracy of current methodologies, and finally two consider the implications of chromosomal mosaicism, which has recently been identified using next-generation sequencing–based chromosome copy number analysis.


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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