Use of preimplantation genetic testing for monogenic defects (PGT-M) for adult-onset conditions: an Ethics Committee opinion

This document discusses the ethical considerations of performing preimplantation genetic testing for monogenic disease to deselect embryos for transfer in order to prevent future adult-onset conditions in the offspring.

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Volume 109, Issue 6, Pages 989–992

Authors:

Ethics Committee of the American Society for Reproductive Medicine

Abstract:

Preimplantation genetic testing for monogenic diseases for adult-onset conditions is ethically permissible for a range of conditions including when the condition is serious and no safe, effective interventions are available. The Committee strongly recommends that a genetic counselor experienced with PGT-M counsel patients considering such procedures. This document replaces the document titled “Use of preimplantation genetic diagnosis for serious adult-onset conditions: a committee opinion,” last published in Fertil Steril 2013;100;54-7.


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Fertility and Sterility

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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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