Pregnancy outcomes from more than 1,800 in vitro fertilization cycles with the use of 24-chromosome single-nucleotide polymorphism–based preimplantation genetic testing for aneuploidy

Selective transfer of embryos determined to be euploid by 24-chromosome single-nucleotide polymorphism–based preimplantation genetic testing for aneuplody demonstrates excellent in vitro fertilization outcomes.

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Volume 110, Issue 1, Pages 113–121

Authors:

Alexander L. Simon, B.S., Michelle Kiehl, M.Sc., Erin Fischer, B.S., J. Glenn Proctor, M.H.A., Mark R. Bush, M.D., Carolyn Givens, M.D., Matthew Rabinowitz, Ph.D., Zachary P. Demko, Ph.D.

Abstract:

Objective

To measure in vitro fertilization (IVF) outcomes following 24-chromosome single‒nucleotide-polymorphism (SNP)–based preimplantation genetic testing for aneuploidy (PGT-A) and euploid embryo transfer.

Design

Retrospective.

Setting

Fertility clinics and laboratory.

Patient(s)

Women 20–46 years of age undergoing IVF treatment.

Intervention(s)

Twenty-four-chromosome SNP-based PGT-A of day 5/6 embryo biopsies.

Main Outcome Measure(s)

Maternal age–stratified implantation, clinical pregnancy, and live birth rates per embryo transfer; miscarriage rates; and number of embryo transfers per patient needed to achieve a live birth.

Result(s)

An implantation rate of 69.9%, clinical pregnancy rate per transfer of 70.6%, and live birth rate per transfer of 64.5% were observed in 1,621 nondonor frozen cycles with the use of SNP-based PGT-A. In addition, SNP-based PGT-A outcomes, when measured per cycle with transfer, remained relatively constant across all maternal ages; when measured per cycle initiated, they decreased as maternal age increased. Miscarriage rates were ∼5% in women ≤40 years old. No statistically significant differences in pregnancy outcomes were found for single-embryo transfers (SET) versus double-embryo transfers with SNP-based PGT-A. On average, 1.38 embryo transfers per patient were needed to achieve a live birth in nondonor cycles.

Conclusion(s)

Our findings that SNP-based PGT-A can mitigate the negative effects of maternal age on IVF outcomes in cycles with transfer, and that pregnancy outcomes from SET cycles are not significantly different from those of double-embryo transfer cycles, support the use of SET when transfers are combined with SNP-based PGT-A.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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