Good-quality blastocysts derived from vacuolized morulas show reduced viability

Late onset of vacuolization around compaction stage is a negative predictor of blastocyst formation and outcome.

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Volume 109, Issue 6, Pages 1025–1029

Authors:

Richard B. Mayer, M.D., Omar Shebl, M.D., Peter Oppelt, M.D., Elisabeth Reiter, M.D., Reinhard Altmann, M.D., S. Enengl, M.D., Christina Allerstorfer, M.D., Thomas Ebner, Ph.D.

Abstract:

Objective

To study whether late spontaneous vacuolization on day 4 is an artefact or an alternate means of blastocele formation and to analyze its impact on pregnancy outcome and live birth.

Design

Prospective observational study.

Setting

University teaching hospital.

Patient(s)

A total of 424 patients who fulfilled inclusion criteria were subgrouped according to the spontaneous vacuolization on day 4: Group 1 had all morulas affected, group 2 showed no signs of vacuoles, and group 3 was mixed (some day 4 embryos had vacuoles and others did not).

Intervention(s)

Screening for the presence of vacuoles on day 4 and fresh single-blastocyst transfer.

Main Outcome Measure(s)

Morula and blastocyst scoring, utilization rate, pregnancy and live birth rates.

Result(s)

Patients of group 1 had a reduced blastocyst formation rate on day 5 (P<.01) and significantly fewer good-quality blastocysts for usage (P<.05). In addition, pregnancy (P<.001) and live birth (P<.01) rate were significantly worse in group 1 compared with groups 2 and 3.

Conclusion(s)

Late onset of vacuolization around compaction stage is a negative predictor of blastocyst formation and outcome.


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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