Antimüllerian hormone as a risk factor for miscarriage in naturally conceived pregnancies

In women with naturally conceived pregnancies, low antimullerian hormone ( 0.4 ng/mL) is associated with an increased risk of miscarriage.

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Volume 109, Issue 6, Pages 1065–1071.e1

Authors:

Brianna M. Lyttle Schumacher, M.D., Anne Marie Z. Jukic, Ph.D., Anne Z. Steiner, M.D., M.P.H.

Abstract:

Objective

To determine the association between antimüllerian hormone (AMH), a measure of ovarian reserve, and miscarriage among naturally conceived pregnancies.

Design

Prospective cohort study.

Setting

Not applicable.

Patient(s)

Women (n = 533), between 30 and 44 years of age with no known history of infertility, polycystic ovarian syndrome, or endometriosis who conceived naturally.

Intervention(s)

None.

Main Outcome Measure(s)

Miscarriage, defined as an intrauterine pregnancy loss before 20 weeks’ gestation.

Result(s)

After adjusting for maternal age, race, history of recurrent miscarriage, and obesity, risk of miscarriage decreased as AMH increased (risk ratio per unit increase in natural log of AMH = 0.83; 95% confidence interval [CI], 0.73, 0.94). Women with severely diminished ovarian reserve (AMH ≤ 0.4 ng/mL) miscarried at over twice the rate of women with an AMH ≥ 1 ng/mL (hazard ratio, 2.3; 95% CI, 1.3, 4.3).

Conclusion(s)

AMH levels are inversely associated with the risk of miscarriage. Women with severely diminished ovarian reserve are at an increased risk of miscarriage.


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1 Comments

Go to the profile of William Stones
William Stones 5 months ago

Thanks for this interesting and detailed work. A question- there is no mention of parity of the participants, only previous miscarriage history. Any reason why that was not included in the demographic table and/or analyses as a covariate?