Antimüllerian hormone among women with and without type 1 diabetes: the Epidemiology of Diabetes Interventions and Complications Study and the Michigan Bone Health and Metabolism Study

Among women aged<35 years, antimullerian hormone concentrations are lower in women with type 1 diabetes compared with women without diabetes.

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Volume 106, Issue 6, Pages 1446-1452

Authors:

Catherine Kim, M.D., M.P.H., Carrie Karvonen-Gutierrez, Ph.D., Shengchun Kong, Ph.D., Valerie Arends, M.S., Michael Steffes, M.D., Ph.D., Daniel S. McConnell, Ph.D., John F. Randolph Jr., M.D., Siobán D. Harlow, Ph.D.

Abstract:

Objective

To compare concentrations of antimüllerian hormone (AMH) in women with and without type 1 diabetes.

Design

Cross-sectional analysis of longitudinal studies, adjusting for repeated measures.

Setting

Michigan Bone Health and Metabolism Study, a community-based population, and the Epidemiology of Interventions and Complications Study, an observational cohort of women with type 1 diabetes.

Patient(s)

Women aged 30–45 years who had not undergone oophorectomy, hysterectomy, or natural menopause at the time of AMH measurement were included (n = 376 in the Michigan Bone Health and Metabolism Study and n = 321 in the Epidemiology of Interventions and Complications Study). Linear mixed regression was used to evaluate whether AMH concentrations differed by diabetes status, adjusting for repeated measurements of AMH within individual women, body mass index, smoking status, and oral contraceptive use.

Intervention(s)

None.

Main Outcome Measure(s)

Concentrations of AMH.

Result(s)

In unadjusted comparisons, women with and without diabetes had similar median AMH values before 35 years of age, although women with type 1 diabetes had a lower proportion of women with elevated AMH concentrations (≥5.0 ng/dL). After adjustment for covariates and multiple observations per woman, log AMH concentrations were significantly lower among women with type 1 diabetes compared with women without diabetes (β-coefficient −1.27, 95% confidence interval [−2.18, −0.36] in fully adjusted models) before 35 years of age.

Conclusion(s)

Before 35 years of age, women with type 1 diabetes have lower AMH levels than women without diabetes. Further investigation is needed to determine the etiologies of this difference and how it may contribute to reproductive disorders among women with type 1 diabetes.


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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