VOLUME 3, ISSUE 3, P292, SEPTEMBER 01, 2022
Richard Bronson, M.D.
A recent article in F&S Reports by Baker et al., “Poor reproducibility of percentage of normally shaped sperm using the World Health Organization Fifth Edition strict grading criteria,” brought to mind some of our relevant prior work. During a discussion a number of years ago at an Andrology Society meeting, we remarked how the field of andrology was still in the dark ages. If we were hematologists, no one would be satisfied with a descriptive diagnosis, such as microcytic anemia, but want to know the etiology. Was it nutritional, such as iron deficiency, or genetic, such as thalassemia? “Teratospermia” is not a diagnosis but only a description of cells. Abnormalities of the sperm shape have been associated with fever, exogenous heat exposure, varicoceles, cigarette smoking, and exposure to polychlorinated biphenyls. Experimental evidence has also been found in mice of gene mutations that lead teratospermia, which may also occur in humans (1, 2).