Can we use in vitro fertilization with preimplantation genetic testing to avoid molar pregnancies?


VOLUME 2, ISSUE 2, P137, JUNE 01, 2021


Richard J. Paulson, M.D., M.S.


Molar pregnancy is a rare but serious complication of conception. If it occurs in conjunction with fertility treatment, it is particularly disruptive, because the female partner must wait for a significant amount of time before attempting conception again to rule out persistent gestational trophoblastic disease (GTD). First described by Hippocrates in ancient Greece as “dropsy of the uterus,” the hydatidiform mole is the result of abnormal fertilization of the oocyte. Because in vitro fertilization (IVF) allows the observation of fertilization as well as early embryonic development, it is tempting to speculate that IVF, particularly if combined with preimplantation genetic testing (PGT), may be used to detect the abnormal fertilization, so that molar pregnancy can be avoided.

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