Follicle-stimulating hormone receptor autoantibody associated primary ovarian insufficiency successfully treated with corticosteroids: a case report
Featured Article
Published
VOLUME 1, ISSUE 3, P206-208, DECEMBER 01, 2020
Authors:
Carrie Riestenberg, M.D., Susan Ahern, D.O., Mousa Shamonki, M.D.
Abstract:
Objective
To report a case of successful controlled ovarian stimulation (COH) for oocyte cryopreservation in a patient with autoimmune primary ovarian insufficiency (POI) and polyglandular autoimmune syndrome (PGAS) type 2.
Design
Case report.
Setting
Private in vitro fertilization clinic.
Patient(s)
25-Year-old woman, G0, with autoimmune POI and PGAS type 2.
Intervention(s)
Diagnosis of autoimmune interference with FSH signaling, with subsequent high-dose corticosteroid immune suppression and successful oocyte cryopreservation.
Main Outcomes Measure(s)
Successful stimulation with exogenous gonadotropins, oocyte retrieval, and cryopreservation.
Result(s)
Retrieval and cryopreservation of 36 metaphase-II (MII) oocytes.
Conclusion(s)
Scrutiny of POI cases will facilitate identification of a subset of patients in whom immune suppression with short-term, high-dose corticosteroids may enable successful COH.
