Are we approaching automated assisted reproductive technology? Embryo culture, metabolomics, and cryopreservation

Review Article

VOLUME 2, ISSUE 4, P251-264, OCTOBER 01, 2021


Valentina Casciani, Ph.D., Daniela Galliano, M.D., Ph.D., Jason M. Franasiak, M.D., Giulia Mariani, M.D., Marcos Meseguer, Ph.D.


For decades, assisted reproductive technology (ART) procedures have been performed manually thanks to the meticulous work of skilled embryologists. Recently, new technologies have been developed with three main scopes: improving embryo culture conditions; making diagnostic evaluations more consistent and reliable; and allowing ART procedures to become progressively less subjective and operator-dependent. This review aimed to answer the following questions: is automation likely to be successfully incorporated into the in vitro fertilization laboratory and clinical ART in the future? If so, would such automation result in improved outcomes in ART?