VOLUME 114, ISSUE 4, P725-738
Authors:
Marie-Madeleine Dolmans, M.D., Ph.D., Hugh S. Taylor, M.D., Kenny A. Rodriguez-Wallberg, M.D., Ph.D., Zeev Blumenfeld, M.D., Matteo Lambertini, M.D., Ph.D., Michael von Wolff, M.D., Jacques Donnez, M.D., Ph.D.
Abstract:
Con: GnRH-a should not be used for fertility preservation in women receiving chemotherapy
Pro: PRO: GnRH-a should be used for fertility preservation in women receiving chemotherapy
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Comments
GnRH helps in Fertility preservation.
The chemotherapeutic drugs are mostly toxic to all cells. However, they are far more toxic to rapidly dividing cells as in the bone marrow, gastro intestinal tract, bone marrow, gonads and hair, than other less rapidly dividing cells. We hypothesized in an article in RBMO in the inaugural issue of the Journal, that GnRH, by gonadal suppression, will reduce the risk of chemotherapy. (1)
The peer reviewers had reservation about this suggestion. However, 20 years later, we find our suggestion seems to work in a large number of people.
1) Pandiyan N. Medical management of male infertility. Reprod Biomed Online. 2000;1(1):13-6. doi: 10.1016/s1472-6483(10)61987-6. PMID: 12804206.
Professor Dr Pandiyan Natarajan,
Apollo 24/7.
Chief Consultant in Andrology and Reproductive Medicine and
Chief Editor, Chettinad Health City Medical Journal,Head of the Department of Reproductive Medicine, ( Retired )
Chettinad Super Speciality Hospital,
Director, International Academic Affiliations,
Chettinad Academy of Research & Education, ( Retired )
www.chcmj.ac.in
https://en.wikipedia.org/wiki/Natarajan_Pandiyan