Ureaplasma parvum alters the immune tolerogenic state in placental tissue and could cause miscarriage

The presence of Ureaplasma parvum increased proinflammatory cytokines (interleukin [IL]-6 and IL-12p70) and negatively regulated the expression of cytokines involved in the immune response against pathogens in spontaneous abortion.

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VOLUME 116, ISSUE 4, P1030-1039

Authors:

Caline Novais Teixeira Oliveira, Ph.D., Maria Tânia S. Oliveira, M.D., Hellen Braga Martins Oliveira, Ph.D., Lucas Santana Coelho Silva, M.D., Manoel Neres Santos Júnior, M.D., Carolline Florentino Almeida, B.Sc., Aline Teixeira Amorim, Ph.D., Márcio Vasconcelos Oliveira, Ph.D., Jorge Timenetsky, Ph.D., Guilherme Barreto Campos, Ph.D., Lucas Miranda Marques, Ph.D. 

Abstract:

Objective

To study the inflammatory profile and genes involved in the response to bacterial infections in women who developed spontaneous abortion in the presence of Ureaplasma parvum.


Design

Cross-sectional study.


Setting

A maternal and child referral center.


Patient(s)

Eighty-nine women with spontaneous abortion and 20 women with normal vaginal delivery (control group) were studied.


Intervention(s)

Samples of biopsied placental tissue were collected for Mollicutes detection.


Main Outcome Measure(s)

The samples were subjected to histologic analysis, immunohistochemical evaluation for macrophages and lymphocytes, cytokine quantification, and quantitative polymerase chain reaction array to evaluate the expression of 84 genes related to the innate and adaptive immune responses.


Result(s)

The presence of U. parvum in the abortion group was positively associated with the influx of polymorphonuclear cells in the placental tissue and increased concentrations of interleukin-6 and interleukin-12p70. U. parvum caused downregulation of genes involved in the immune response, such as attraction of immune cells, activation of an inflammatory response, T-helper cell 17 response activation, and activation of the complement system at the beginning and end of pregnancy.


Conclusion

The direct action of U. parvum on placental tissue altered the gestational tolerogenic state, reducing the immune response against pathogens and activating the extrinsic apoptotic pathway, causing spontaneous abortion.

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.