Two peas from the same pod: vanishing follicles and postmature oocytes
Article In Press
Dmitri I. Dozortsev, M.D., Ph.D., Michael P. Diamond, M.D.
During ovarian stimulation, on occasion, a previously identified follicle can no longer be located. This phenomenon, known as a vanishing follicle, has an increasing prevalence with advancing age (1). A postmature egg, a more obscured spectacle, referred to an oocyte that at retrieval has the appearance of the oocyte aged in vitro without fertilization for >1 day. Furthermore, similarly to an in vitro aged oocyte, it may become fertilized and cleave, but extremely rarely develops to the blastocyst and never implants. Surprisingly, despite the common realization of the existence of postmature oocytes, no definition for this phenomenon can be found in the literature, and their origin remains completely unknown.