Time to revisit the adage: relax and you will get pregnant

50 Years Ago Today

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VOLUME 116, ISSUE 3, P695


Eve C. Feinberg, M.D., Jessica Tozour, M.D.


“What is now proved was once only imagined”– William Blake

The September 1971 issue of Fertility and Sterility contains the article “The contractile response of the human uterus, fallopian tubes, and ovary to prostaglandins in vivo” by Countinho and Maia (1). This was the first study to evaluate the in vivo effects of prostaglandin F2 (PGF2) and prostaglandin E2 (PGE2) on the ovary, uterus, and fallopian tube. A recording device to monitor contractility was placed into the fallopian tube lumen of eight subjects and into the fibromuscular tissue of the ovarian stroma. Uterine activity was recorded by an intrauterine balloon. Either PGE2, PGF2, or both were infused and contractility was recorded.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. 


Go to the profile of Pandiyan  Natarajan
3 months ago
Beggar belief to expect 100% pregnancy rate or even close to it.

I read with considerable interest the interesting article on , “ Time to revisit the adage: relax and you will get pregnant.” The article, I feel, is a bit ambitious.

 It is true that great advances have happened in the field of Assisted Reproduction since the birth of Louis Browne. However, we have still not bettered Nature. The Natural pregnancy rate in fertile young people is about 25%. This is with single oocyte. With all our advances and some unproven or questionable advances, we are no where near this rate. To expect 100% pregnancy rate is Utopian. 

I think we should focus on Prevention of Infertility rather than hoping to improve ART pregnancy rates with all its attendant risks. The commonest cause of Infertility today is Unexplained or Age related decline in Fertility. We should encourage to couple to have children in their twenties and not postpone till their late thirties and then fight against nature and declining fertility.

Professor Dr Pandiyan Natarajan,


Thilakam Natarajan Reproductive Health Center,

Chennai./Cary./Los Angeles.