Time to revisit the adage: relax and you will get pregnant

50 Years Ago Today

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VOLUME 116, ISSUE 3, P695


Eve C. Feinberg, M.D., Jessica Tozour, M.D.


“What is now proved was once only imagined”– William Blake

The September 1971 issue of Fertility and Sterility contains the article “The contractile response of the human uterus, fallopian tubes, and ovary to prostaglandins in vivo” by Countinho and Maia (1). This was the first study to evaluate the in vivo effects of prostaglandin F2 (PGF2) and prostaglandin E2 (PGE2) on the ovary, uterus, and fallopian tube. A recording device to monitor contractility was placed into the fallopian tube lumen of eight subjects and into the fibromuscular tissue of the ovarian stroma. Uterine activity was recorded by an intrauterine balloon. Either PGE2, PGF2, or both were infused and contractility was recorded.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.