The “mosaic” embryo: misconceptions and misinterpretations in preimplantation genetic testing for aneuploidy

Current methods of predicting mosaicism are inaccurate and have led to numerous misinterpretations and misconceptions regarding its clinical significance

Like Comment
Related Content

VOLUME 116, ISSUE 5, P1205-1211

Authors:

Nathan R. Treff, Ph.D., Diego Marin, Ph.D.

Abstract:

Preimplantation genetic testing for aneuploidy (PGT-A) remains one of the most controversial topics in reproductive medicine. With more than 40% of in vitro fertilization cycles in the United States reportedly involving PGT, both those in favor of and those opposed to PGT-A have significant interest in the efficacy of PGT-A. Ongoing issues include what patient population, if any, benefits from PGT-A, the true frequency of chromosomal mosaicism, whether embryonic aneuploidies self-correct, and how practitioners manage embryos designated as “mosaic.” This review addresses several misconceptions and misinterpretations of data surrounding the genetic analysis and prediction of mosaicism in the preimplantation embryo.

Read the full text here. 

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. 

Comments

Go to the profile of charlotte.coat
20 days ago

About your Figure 3. It's a very interesting information. We potentially miss informations due to this noise.

We can modify the noise level by using different filters on NGS platform, isn't it ?

Thanks