The impact of SARS-CoV-2 and COVID-19 on male reproduction and men’s health

SARS-CoV-2 is unlikely to be detected in human semen, but viral tropism for the male reproductive tract and the impact on both male hormones and semen parameters remains incompletely characterized.
The impact of SARS-CoV-2 and COVID-19 on male reproduction and men’s health

VOLUME 115, ISSUE 4, P813-823


Darshan P. Patel, M.D., Nahid Punjani, M.D., MPH, Jingtao Guo, Ph.D., Joseph P. Alukal, M.D., Philip S. Li, M.D., James M. Hotaling, M.D., MS 


Many couples initially deferred attempts at pregnancy or delayed fertility care due to concerns about coronavirus disease 2019 (COVID-19). One significant fear during the COVID-19 pandemic was the possibility of sexual transmission. Many couples have since resumed fertility care while accepting the various uncertainties associated with severe acute respiratory syndrome coronavirus 2, including the evolving knowledge related to male reproductive health. Significant research has been conducted exploring viral shedding, tropism, sexual transmission, the impact of male reproductive hormones, and possible implications to semen quality. However, to date, limited definitive evidence exists regarding many of these aspects, creating a challenging landscape for both patients and physicians to obtain and provide the best clinical care. This review provides a comprehensive assessment of the evolving literature concerning COVID-19 and male sexual and reproductive health, and guidance for patient counseling.


Go to the profile of Milad Zandi
about 1 year ago

I read with interest review article by Dr Darshan et al.  I appreciate their work, however, in SARS-CoV-2 Taxonomy section, they stated "SARS-CoV-2 has the largest genome among known RNA viruses", this sentence is scientifically incorrect because of its reported that planarian secretory cell nidovirus is the largest RNA genome among all known RNA viruses.