The association of euploid miscarriage with obesity

Original Articles: Early Pregnancy

VOLUME 1, ISSUE 2, P142-148, SEPTEMBER 01, 2020


Jacqueline C. Lee, M.D., Lia A. Bernardi, M.D., M.S.C.I., Christina E. Boots, M.D., M.S.C.I.



To determine whether the frequency of euploid miscarriage is increased in obese women with early pregnancy loss.


Retrospective cohort study.


Academic medical center.


A total of 2,620 women with cytogenetic analysis results from products of conception after a pregnancy loss <20 weeks gestation from 2006–2018.



Main Outcome Measure(s)

Frequency of euploid miscarriage was compared in obese (body mass index [BMI] ≥30 kg/m2) versus non-obese (BMI <30 kg/m2) patients.


A total of 2,620 women with a mean (± standard deviation) age at time of loss of 34.9 years (± 4.9) and mean (± standard deviation) BMI of 25.3 kg/m2 (±5.5) were included in the final analysis. After adjusting for age and race, obese women were 56% more likely to have a euploid pregnancy loss compared with nonobese women (odds ratio 1.56; 95% confidence interval 1.32–1.92). Within the cohort, 63.8% of the losses were aneuploid, of which 41% were trisomies, 8% were monosomies, and 7% were polyploidies. Of the euploid losses, 50.1% were 46,XX and 49.9% were 46,XY, which suggests that the rate of maternal cell contamination was low.


Obese women have an increased frequency of euploid miscarriage when compared with nonobese women.