The association of euploid miscarriage with obesity

Original Articles: Early Pregnancy

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VOLUME 1, ISSUE 2, P142-148, SEPTEMBER 01, 2020

Authors:

Jacqueline C. Lee, M.D., Lia A. Bernardi, M.D., M.S.C.I., Christina E. Boots, M.D., M.S.C.I.

Abstract:

Objective

To determine whether the frequency of euploid miscarriage is increased in obese women with early pregnancy loss.


Design

Retrospective cohort study.


Setting

Academic medical center.


Patient(s)

A total of 2,620 women with cytogenetic analysis results from products of conception after a pregnancy loss <20 weeks gestation from 2006–2018.


Intervention(s)

None.


Main Outcome Measure(s)

Frequency of euploid miscarriage was compared in obese (body mass index [BMI] ≥30 kg/m2) versus non-obese (BMI <30 kg/m2) patients.


Result(s)

A total of 2,620 women with a mean (± standard deviation) age at time of loss of 34.9 years (± 4.9) and mean (± standard deviation) BMI of 25.3 kg/m2 (±5.5) were included in the final analysis. After adjusting for age and race, obese women were 56% more likely to have a euploid pregnancy loss compared with nonobese women (odds ratio 1.56; 95% confidence interval 1.32–1.92). Within the cohort, 63.8% of the losses were aneuploid, of which 41% were trisomies, 8% were monosomies, and 7% were polyploidies. Of the euploid losses, 50.1% were 46,XX and 49.9% were 46,XY, which suggests that the rate of maternal cell contamination was low.


Conclusion(s)

Obese women have an increased frequency of euploid miscarriage when compared with nonobese women.

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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