The association of euploid miscarriage with obesity

Original Articles: Early Pregnancy

VOLUME 1, ISSUE 2, P142-148, SEPTEMBER 01, 2020

Authors:

Jacqueline C. Lee, M.D., Lia A. Bernardi, M.D., M.S.C.I., Christina E. Boots, M.D., M.S.C.I.

Abstract:

Objective

To determine whether the frequency of euploid miscarriage is increased in obese women with early pregnancy loss.


Design

Retrospective cohort study.


Setting

Academic medical center.


Patient(s)

A total of 2,620 women with cytogenetic analysis results from products of conception after a pregnancy loss <20 weeks gestation from 2006–2018.


Intervention(s)

None.


Main Outcome Measure(s)

Frequency of euploid miscarriage was compared in obese (body mass index [BMI] ≥30 kg/m2) versus non-obese (BMI <30 kg/m2) patients.


Result(s)

A total of 2,620 women with a mean (± standard deviation) age at time of loss of 34.9 years (± 4.9) and mean (± standard deviation) BMI of 25.3 kg/m2 (±5.5) were included in the final analysis. After adjusting for age and race, obese women were 56% more likely to have a euploid pregnancy loss compared with nonobese women (odds ratio 1.56; 95% confidence interval 1.32–1.92). Within the cohort, 63.8% of the losses were aneuploid, of which 41% were trisomies, 8% were monosomies, and 7% were polyploidies. Of the euploid losses, 50.1% were 46,XX and 49.9% were 46,XY, which suggests that the rate of maternal cell contamination was low.


Conclusion(s)

Obese women have an increased frequency of euploid miscarriage when compared with nonobese women.