Testosterone administration increases leukocyte-endothelium interactions and inflammation in transgender men

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Authors:

Francesca Iannantuoni, Ph.D., Juan Diego Salazar, Ph.D., Aranzazu Martinez de Maranon, Ph.D., Celia Banuls, Ph.D., Sandra Lopez-Domenech, Ph.D., Milagros Rocha, Ph.D., Felipe Hurtado-Murillo, M.D., Ph.D., Carlos Morillas, M.D., Ph.D., Marcelino Gomez-Balaguer, M.D., Ph.D., Víctor Manuel Víctor, Ph.D.

Abstract:

Objective

To evaluate the effect of testosterone treatment on metabolic and inflammation parameters and leukocyte-endothelium interactions in transgender men (TGM).


Design

Prospective observational study.


Setting

University hospital.


Patient(s)

One hundred fifty-seven TGM.


Intervention(s)

Administration of testosterone undecanoate (1,000 mg, intramuscular) every 12 weeks.


Main Outcome Measure(s)

Endocrine parameters, adhesion molecules (vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, and E-selectin), proinflammatory cytokines interleukin-6, and tumor necrosis factor alpha were evaluated in serum before and after treatment using Luminex’s xMAP technology. In addition, interactions between human umbilical vein endothelial cells and polymorphonuclear leukocytes were assessed by flow chamber microscopy.


Result(s)

Testosterone treatment led to an increase in leukocyte-endothelium interactions due to an increase in polymorphonuclear leukocytes rolling and adhesion and decreased rolling velocity. It also boosted levels of vascular cell adhesion molecule-1, E-selectin, interleukin-6, and tumor necrosis factor alpha. As expected, testosterone also produced a significant increase in free androgenic index, androstenedione, total testosterone, and atherogenic index of plasma and a decrease in sex hormone–binding globulin and high-density lipoprotein cholesterol.


Conclusion(s)

Treatment of TGM with testosterone induces an increase in leukocyte-endothelium interactions and adhesion molecules and proinflammatory cytokines. These effects are a reason to monitor cardiovascular risk in these patients.

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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