Should preimplantation genetic testing for polygenic disease be offered to all – or none?

Fertile Battle
Should preimplantation genetic testing for polygenic disease be offered to all – or none?
Like

VOLUME 117, ISSUE 6, P1162-1167

Authors:

Nathan R. Treff, Ph.D., Julian Savulescu, Ph.D., Inmaculada de Melo-Martín, Ph.D., Lee P. Shulman, M.D., Eve C. Feinberg, M.D. 

Abstract:

PRO: Preimplantation genetic testing (PGT) for polygenic disease should be offered to all

CON: PGT for polygenic disease should be offered to none

Read the full text here.

Please sign in or register for FREE

Your Fertility and Sterility Dialog login information is not the same as your ASRM or EES credentials. Users must create a separate account to comment or interact on the Dialog.

Go to the profile of Pandiyan  Natarajan
about 2 months ago
Preimplantation genetic testing for polygenic disease should be offered to- NONE.

Polygenic disease is a nebulous term. The term was introduced to explain conditions like Type 2 Diabetes Mellitus & Hypertension which run in families with no clearly discernible single gene defect. We forget that in all these conditions Epigenetic Factors play a bigger role compared to Genetics.

Preimplantation Genetic Testing for Aneuploidy is in a quandary. At this stage to introduce PGT for polygenic disease would create a brouhaha and considerable harm to the couple and the embryo.

Preimplantation genetic testing for polygenic disease should be offered to- NONE.

Professor Dr Pandiyan Natarajan,

Chief Consultant in Andrology and Reproductive Sciences,

Apollo 24/7, NOVA IVF FERTILITY,

Chettinad Super Speciality Hospital ( Retired )

Professor Emeritus, The Tamil Nadu Dr MGR Medical University.