S1P and activin A induce fibrotic phenotype in uterine fibroids: a promising target for antifibrotic therapy

Reflections
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Editorial Office, American Society for Reproductive Medicine
S1P and activin A induce fibrotic phenotype in uterine fibroids: a promising target for antifibrotic therapy
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S1P and activin A induce fibrotic phenotype in uterine fibroids: a promising target for antifibrotic therapy

Uterine fibroids are characterized by excessive deposition of extracellular matrix (ECM) proteins, such as collagens, fibronectin, and proteoglycans that characterize fibrosis. Collagens in fibroids contribute to fibroid stiffness and increased mechanical stress is translated into biochemical signal…

VOLUME 115, ISSUE 6, P1451-1452

Authors:

Md Soriful Islam, Ph.D., Most Mauluda Akhtar, Ph.D., James H. Segars, M.D.

Abstract:

Reflections on "Sphingosine 1-phosphate signaling in uterine fibroids: implication in activin A pro-fibrotic effect" by Bernacchioni et al.

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Fertility and Sterility
Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. 

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