Recurrent pregnancy losses, a lasting cause of infertility

Early miscarriage occurs in approximately 12% to 15% of all pregnancies, an incidence that increases with age. Recurrent pregnancy loss (2–3 miscarriages) affects nearly 1% to 2% of women

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VOLUME 115, ISSUE 3, P531-532, MARCH 01, 2021


Dominique de Ziegler, M.D., Rene F. Frydman, M.D.


Recurrent pregnancy loss (RPL), defined as two to three spontaneous pregnancy terminations occurring before 12 weeks of gestation, affects approximately 1% of the general population. The causes may include congenital factors that originate with the quality of the gametes (sperm or oocyte) or the resulting embryo, or factors that originate within the uterus. Alterations of endometrial receptivity from endometriosis and/or endometritis, which are associated with impaired action of progesterone, have also been implicated in RPL. Finally, immunologic factors and thrombophilia, congenital and acquired, have also been suspected to cause RPL.

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.